Monday, October 17, 2011

Passage on immunosuppressive effects of D3 from previously-mentioned blog

In the 2nd previous post, I referred to a blog page entitled Flu Season is Here, and I've since realized that I should have copied just a certain key section. So, here it is, without any comments from myself:


The active vitamin D metabolite 1,25-dihydroxyvitamin D3 [1,25-D3] is thought to promote many of its actions through interaction with a specific intracellular receptor. The discovery of such receptors in monocytes and activated lymphocytes has led investigators to evaluate the role of the hormone on the immune system. The sterol inhibits lymphocyte proliferation and immunoglobulin production in a dose-dependent fashion. At a molecular level, 1,25-D3 inhibits the accumulation of mRNA for IL-2, IFN-γ, and GM-CSF. At a cellular level, the hormone interferes with T helper cell (Th) function, reducing Th-induction of immunoglobulin production by B cells and inhibiting the passive transfer of cellular immunity by Th-clones in vivo. The sterol promotes suppressor cell activity and inhibits the generation of cytotoxic and NK cells. Class II antigen expression on lymphocytes and monocytes is also affected by the hormone.

When given in vivo, 1,25-D3 has been particularly effective in the prevention of autoimmune diseases such as experimental autoimmune encephalomyelitis and murine lupus but its efficacy has been limited by its hypercalcemic effect. Synthetic vitamin D3 analogues showing excellent 1,25-D3-receptor binding but less pronounced hypercalcemic effects in vivo have recently enhanced the immunosuppressive properties of the hormone in autoimmunity and transplantation."

Why anyone would take this in excess is beyond me. I can only imagine they are buying the hype that D3 is a wonderdrug. Yea, it's a wonder drug... if you need to suppress your immune system, then its your golden ticket.

I do think the worsening trend of flu and cold viruses may be related to the trend to normal healthy people taking way too much vitamin D3. We are walking around potentially immunosuppressed because of this OTC drug we are ignorantly taking and we don't know it.
This is similar to the vitamin D3 hype... in reality this is nothing more than an immunosuppressant. That may be good for inflammation (diabetes, heart disease, etc) and for autoimmunity (MS, lupus, etc) but it is horrible for healthy people.