Monday, October 17, 2011

Passage on immunosuppressive effects of D3 from previously-mentioned blog

In the 2nd previous post, I referred to a blog page entitled Flu Season is Here, and I've since realized that I should have copied just a certain key section. So, here it is, without any comments from myself:


The active vitamin D metabolite 1,25-dihydroxyvitamin D3 [1,25-D3] is thought to promote many of its actions through interaction with a specific intracellular receptor. The discovery of such receptors in monocytes and activated lymphocytes has led investigators to evaluate the role of the hormone on the immune system. The sterol inhibits lymphocyte proliferation and immunoglobulin production in a dose-dependent fashion. At a molecular level, 1,25-D3 inhibits the accumulation of mRNA for IL-2, IFN-γ, and GM-CSF. At a cellular level, the hormone interferes with T helper cell (Th) function, reducing Th-induction of immunoglobulin production by B cells and inhibiting the passive transfer of cellular immunity by Th-clones in vivo. The sterol promotes suppressor cell activity and inhibits the generation of cytotoxic and NK cells. Class II antigen expression on lymphocytes and monocytes is also affected by the hormone.

When given in vivo, 1,25-D3 has been particularly effective in the prevention of autoimmune diseases such as experimental autoimmune encephalomyelitis and murine lupus but its efficacy has been limited by its hypercalcemic effect. Synthetic vitamin D3 analogues showing excellent 1,25-D3-receptor binding but less pronounced hypercalcemic effects in vivo have recently enhanced the immunosuppressive properties of the hormone in autoimmunity and transplantation."

Why anyone would take this in excess is beyond me. I can only imagine they are buying the hype that D3 is a wonderdrug. Yea, it's a wonder drug... if you need to suppress your immune system, then its your golden ticket.

I do think the worsening trend of flu and cold viruses may be related to the trend to normal healthy people taking way too much vitamin D3. We are walking around potentially immunosuppressed because of this OTC drug we are ignorantly taking and we don't know it.
This is similar to the vitamin D3 hype... in reality this is nothing more than an immunosuppressant. That may be good for inflammation (diabetes, heart disease, etc) and for autoimmunity (MS, lupus, etc) but it is horrible for healthy people.

Sunday, October 16, 2011

An anti-Vit D3 supplement perspective

Now that my mind has been opened to the possibility that Vit D3-pushers might have a nefarious agenda, I decided to post a link to an article entitled The Vitamin D Scam?, which was written by a chemist. It seems that, as I suspected a while back, that Vit D3 is a poor substitute for the array of substances generated by sunlight exposure, and that the body automatically stops producing them when it has obtained a sufficient amount, even if the sunlight exposure continues.

Saturday, October 15, 2011

Large amounts of Vit D3 might be causing my sinus problem

As a result of searching for a potential connection between taking 6,000 IU per day of D3, as recommended by various sources listed in previous posts related to cardiovascular disease, I found some indications on a page entitled Flu Season is Here that the D3 might explain my sinus problems, but the following one especially resonated with me:
The links I posted clearly elucidate the mechanisms by which vitamin D3 suppresses the immune system. This completely matches my experience, and others experience. I did not take a "megadose" of vitamin D3, I only took 2200 iu daily. This was enough to ensure I WAS CHRONICALLY FIGHTING OFF VIRUSES AND NOT WINNING.... [emphasis added]
Another post, by Kurt G. Harris MD, states:

Last winter 2009-2010 was the only winter I ever supplemented with D3 - at about 4000 iu/day up to about 65 ng/dl.

Last winter I got the worst virus I ever had and was sick with cough and bronchospasm for weeks afterward. Most winters I catch nothing or get it very mild if at all.

I stopped supplementing with D in march 2010. I do get 20 minute of sun from march through september, but I let my D levels fall naturally the way I have for the past 5 years or so. This winter - 2010-2011 - my wife, who still supplements at 2-4000/day, caught a nasty URI that put her in bed for 4 days. I slept with her and did not get sick at all.
So, for what it's worth, there does seem to be a reason to suspect that my sinus problems might be related to my Vit D3 consumption, and that taking lower doses won't lead to cardiovascular problems. So, I'll experiment with lower doses and see what happens.

Vast site on Candidiasis

In the course of researching a potential link between excess Vit D and candida, I stumbled onto The Chronic Candidiasis Syndrome website, which seems to have a lot of reliable candida-related information.

Thursday, October 06, 2011

Green tea extract vs. candida
Cultures treated with 1.0 micromol/l of epigallocatechin-3-gallate (eGCG), the most abundant polyphenol of green tea, displayed a 75% reduction of viable cells during candida biofilm formation. What was really incredible was that established biofilms treated with eGCG were reduced by 80%. Identical concentrations of other green tea polyphenols (e.g., epigallocatechin and epicatechin-3-gallate) demonstrated similar biofilm inhibition. additional investigation found the green tea polyphenols disrupt candida metabolism and structural components.

Low stomach acid can create dangerous candida overgrowth

Of possibly much greater concern is this colonization which, from our recent study of the literature, we fear: (1) can result in high mortality unless corrected promptly; (2) has been recognized since the early 1980's and identified as a cause of multiple organ failure and other lethal syndromes (Joshi et al 1981; Roy and McCallum, 1984; Marshall et al, 1988);* (3) has gone unread because of both the time pressures on physicians today and the shear size of the 40 million pp/decade of indexed medical science research literature received at our library (it isn't possible to even turn 40 million pp in a decade); and (4) finally colonization occurs when Candida from the mouth are able to pass thru the stomach because its acid is reduced by any of numerous procedures still common today including over-the-counter proton pump inhibitors and even habitual use of antacid tablets.

There are those who claim that indigestion is typically caused by LOW stomach acid, not excess stomach acid.

Wednesday, October 05, 2011

Effectiveness of lufenuron treatment depends on immune system health

In order for Lufenuron to be effective, your immune system has to be in good condition. There are plenty of other sites that address that topic.